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Cystatin C is directly implicated in the elevation of hyperhomocysteinemia; note: (a) OE-CYSC MC showed a significant increase in CYSC expression, while CYSC expression was reduced more than threefold in Si-CYSC MC; (b) the levels of HCY were observed in the culture supernatants from OE-CYSC MC compared with the control ( ***p < 0.05) and OE-NC groups (* p < 0.05). Conversely, reduced levels of HCY were detected in the culture supernatants from the Si-CYSC group compared with the control ( ***p < 0.05) and Si-NC groups ( **p < 0.05). CYSC: cystatin C; HCY: homocysteine; MC: <t>mesangial</t> cell; NC: negative control.
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Cystatin C is directly implicated in the elevation of hyperhomocysteinemia; note: (a) OE-CYSC MC showed a significant increase in CYSC expression, while CYSC expression was reduced more than threefold in Si-CYSC MC; (b) the levels of HCY were observed in the culture supernatants from OE-CYSC MC compared with the control ( ***p < 0.05) and OE-NC groups (* p < 0.05). Conversely, reduced levels of HCY were detected in the culture supernatants from the Si-CYSC group compared with the control ( ***p < 0.05) and Si-NC groups ( **p < 0.05). CYSC: cystatin C; HCY: homocysteine; MC: <t>mesangial</t> cell; NC: negative control.
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Cystatin C is directly implicated in the elevation of hyperhomocysteinemia; note: (a) OE-CYSC MC showed a significant increase in CYSC expression, while CYSC expression was reduced more than threefold in Si-CYSC MC; (b) the levels of HCY were observed in the culture supernatants from OE-CYSC MC compared with the control ( ***p < 0.05) and OE-NC groups (* p < 0.05). Conversely, reduced levels of HCY were detected in the culture supernatants from the Si-CYSC group compared with the control ( ***p < 0.05) and Si-NC groups ( **p < 0.05). CYSC: cystatin C; HCY: homocysteine; MC: <t>mesangial</t> cell; NC: negative control.
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Cystatin C is directly implicated in the elevation of hyperhomocysteinemia; note: (a) OE-CYSC MC showed a significant increase in CYSC expression, while CYSC expression was reduced more than threefold in Si-CYSC MC; (b) the levels of HCY were observed in the culture supernatants from OE-CYSC MC compared with the control ( ***p < 0.05) and OE-NC groups (* p < 0.05). Conversely, reduced levels of HCY were detected in the culture supernatants from the Si-CYSC group compared with the control ( ***p < 0.05) and Si-NC groups ( **p < 0.05). CYSC: cystatin C; HCY: homocysteine; MC: mesangial cell; NC: negative control.

Journal: Science Progress

Article Title: Cystatin C is a potential biomarker for predicting hyperhomocysteinemia associated with chronic kidney disease : A retrospective cross-sectional study

doi: 10.1177/00368504251385932

Figure Lengend Snippet: Cystatin C is directly implicated in the elevation of hyperhomocysteinemia; note: (a) OE-CYSC MC showed a significant increase in CYSC expression, while CYSC expression was reduced more than threefold in Si-CYSC MC; (b) the levels of HCY were observed in the culture supernatants from OE-CYSC MC compared with the control ( ***p < 0.05) and OE-NC groups (* p < 0.05). Conversely, reduced levels of HCY were detected in the culture supernatants from the Si-CYSC group compared with the control ( ***p < 0.05) and Si-NC groups ( **p < 0.05). CYSC: cystatin C; HCY: homocysteine; MC: mesangial cell; NC: negative control.

Article Snippet: The HBZY-1 rat glomerulus-derived mesangial cell (MC) line was obtained from YEASEN (Shanghai, China).

Techniques: Expressing, Control, Negative Control